Soybean-derived antihypertensive hydrolysates attenuate Ang II-induced renal damage by modulating MAPK and NF-κB signaling pathways
Tianyuan Song, Yin‐Yi Ding, Tiantian Zhang, Qiaolin Cai, Yonghong Hu, Qing Gu, Zhenyu Gu
Abstract
HK-2 cell model demonstrated that SPH exhibited optimal activity for reducing Ang II-induced inflammatory cytokines and ROS overproduction. Mechanistically, SPH was observed to regulate MAPK/JNK and NF-κB signaling pathways. These findings indicate that potent antihypertensive SPH significantly ameliorates hypertension-induced kidney damage.
Topics & Concepts
MAPK/ERK pathwayAngiotensin IIRenin–angiotensin systemMedicineKidneySignal transductionPharmacologyEndocrinologyNF-κBInternal medicineChemistryReceptorBlood pressureInflammationBiochemistryAdvanced Glycation End Products researchProtein Hydrolysis and Bioactive PeptidesRenin-Angiotensin System Studies