Austalide derivative from marine-derived <i>Aspergillus</i> sp. and evaluation of its cytotoxic and ADME/TOPKAT properties
Mohamed S. Elnaggar, Ahmed M. Elissawy, Fadia S. Youssef, Máté Kicsák, Tibor Kurtán, Abdel Nasser B. Singab, Rainer Kalscheuer
Abstract
New meroterpenoid derivative (austalide Z) isolated from the marine-derived fungal endophyte Aspergillus sp. with 9 known compounds. Cytotoxic evaluation of the isolated compounds against Caco-2 cell lines reveal weak to moderate activities.
Topics & Concepts
ADMEChemistryStereochemistryEthyl acetatePharmacokineticsPharmacologyChromatographyIn vitroBiochemistryBiologyMicrobial Natural Products and BiosynthesisMarine Sponges and Natural ProductsSynthetic Organic Chemistry Methods