Nanoparticulates reduce tumor cell migration through affinity interactions with extracellular migrasomes and retraction fibers
Yuxi Cheng, Junji Ren, Shumin Fan, Peiyao Wu, Wenshu Cong, Yuxing Lin, Shaojie Lan, Siyang Song, Bin Shao, Wenbing Dai, Xueqing Wang, Hua Zhang, Bo Xu, Wenzhe Li, Xia Yuan, Bing He, Qiang Zhang
Abstract
interaction with lipid raft/caveolae substructures. In this way, NPs block the recognition, endocytosis and elimination of migrasomes by their surrounding tumor cells. Thereby, NPs interfere with the cell-ECM interaction and reduce the promotion effect of migrasomes on cell movement. Additionally, NPs trigger alteration of the expression of proteins related to cell-cell adhesion and cytoskeleton organization, which also restricts cell migration. In summary, all the findings here provide a potential target for anti-tumor metastasis nanomedicines.
Topics & Concepts
Extracellular matrixCell biologyEndocytosisCellCancer cellChemistryCell adhesionCancerBiologyBiochemistryGeneticsNanoparticle-Based Drug DeliveryExtracellular vesicles in diseaseNanoplatforms for cancer theranostics