Copper‐Catalyzed Enantioselective Cyano(Fluoro)Alkylation of Alkenes
Muhammad Israr, Haigen Xiong, Yajun Li, Hongli Bao
Abstract
Abstract A copper‐catalyzed asymmetric cyano(fluoro)alkylation reaction of alkenes is reported. A range of chiral fluoroalkyl cyanides were obtained in high yields and excellent enantiomeric excess from readily available chemicals. The method uses fluoroalkyl iodides as the fluoroalkyl source and employs mild conditions. The peroxide LPO plays a significant role in promotion of this radical asymmetric reaction. magnified image
Topics & Concepts
ChemistryEnantioselective synthesisAlkylationEnantiomerCatalysisCopperEnantiomeric excessOrganic chemistryPeroxideCombinatorial chemistryFluorine in Organic ChemistryRadical Photochemical ReactionsCatalytic C–H Functionalization Methods