Total Synthesis of Lissodendoric Acid A
Francesca M. Ippoliti, Laura G. Wonilowicz, Nathan J. Adamson, Evan R. Darzi, Joyann S. Donaldson, Daniel J. Nasrallah, Milauni M. Mehta, Andrew V. Kelleghan, K. N. Houk, Neil K. Garg
Abstract
We describe a full account of our synthetic strategy leading to the first total synthesis of the manzamine alkaloid lissodendoric acid A . These efforts demonstrate that strained cyclic allenes are valuable synthetic building blocks and can be employed efficiently in total synthesis.
Topics & Concepts
Total synthesisAlkaloidChemistryStereochemistryChemical synthesis and alkaloidsAlkaloids: synthesis and pharmacologyMarine Sponges and Natural Products