Worldwide secular trends in age at pubertal onset assessed by breast development among girls: a systematic review and meta-analysis
Camilla Eckert‐Lind, Busch As, Petersen JH, FM Biro, Gary Butler, Brauner EV, A Juul
Abstract
The authors evaluated the change in pubertal onset in healthy girls around the world based on age at thelarche. Overall, the age at thelarche decreased 0.24 years per decade from 1977 to 2013. This decrease seems to reflect a worldwide trend.
Topics & Concepts
MedicineMenarcheSecular variationBreast developmentMeta-analysisDemographyPopulationEthnic groupData extractionSystematic reviewMEDLINEGynecologyInternal medicineEnvironmental healthLawSociologyPolitical scienceAnthropologyHormoneCancer Risks and FactorsOvarian cancer diagnosis and treatmentHypothalamic control of reproductive hormones