Truncation of Tau selectively facilitates its pathological activities
Jianlan Gu, Wen Xu, Nana Jin, Longfei Li, Yan Zhou, Dandan Chu, Cheng‐Xin Gong, Khalid Iqbal, Fei Liu
Abstract
and in cultured cells. These findings suggest that the first 150 aa and the last 50 aa protect Tau from pathological characteristics and that their deletions facilitate pathological activities. Thus, inhibition of Tau truncation may represent a potential therapeutic approach to suppress Tau pathology in AD and related tauopathies.
Topics & Concepts
Tau proteinPhosphorylationChemistryTauopathyProteasesBiochemistryNeurodegenerationMolecular biologyAlzheimer's diseaseCell biologyBiologyDiseaseMedicinePathologyEnzymeAlzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchCholinesterase and Neurodegenerative Diseases