The lipid transfer properties of CETP define the concentration and composition of plasma lipoproteins
Richard E. Morton, Yan Liu
Abstract
A1) was reduced up to 40%. However, HDL-associated CE excretion into feces was unchanged. We conclude that expression of human CETP in hamsters humanizes their lipoprotein profile with respect to the relative concentrations of VLDL, LDL, HDL, and the HDL3:HDL2 ratio. Altering the lipid substrate preference of CETP provides a novel approach for modifying plasma lipoproteins.
Topics & Concepts
Cholesterylester transfer proteinHamsterEndocrinologyVery low-density lipoproteinInternal medicineCholesterolReverse cholesterol transportChemistryLipoproteinBiologyBiochemistryMedicinePeroxisome Proliferator-Activated ReceptorsCholesterol and Lipid MetabolismDiabetes, Cardiovascular Risks, and Lipoproteins