Litcius/Paper detail

Design, synthesis, and biological evaluation of N-(3-cyano-1H-indol-5/6-yl)-6-oxo-1,6-dihydropyrimidine-4-carboxamides and 5-(6-oxo-1,6-dihydropyrimidin-2-yl)-1H-indole-3-carbonitriles as novel xanthine oxidase inhibitors

Bing Zhang, Yulin Duan, Yuwei Yang, Qing Mao, Fengwei Lin, Jun Gao, Xiwen Dai, Peng Zhang, Qiuhua Li, Jinxin Li, Ronghua Dai, Shaojie Wang

2021European Journal of Medicinal Chemistry29 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryIndole testStereochemistryXanthine oxidaseAllopurinolPharmacophorePotencyMoietyIC50AmideFebuxostatEnzymeHyperuricemiaIn vitroBiochemistryUric acidMedicinePathologyGout, Hyperuricemia, Uric AcidEosinophilic Disorders and SyndromesUrticaria and Related Conditions