Design, synthesis, and biological evaluation of N-(3-cyano-1H-indol-5/6-yl)-6-oxo-1,6-dihydropyrimidine-4-carboxamides and 5-(6-oxo-1,6-dihydropyrimidin-2-yl)-1H-indole-3-carbonitriles as novel xanthine oxidase inhibitors
Bing Zhang, Yulin Duan, Yuwei Yang, Qing Mao, Fengwei Lin, Jun Gao, Xiwen Dai, Peng Zhang, Qiuhua Li, Jinxin Li, Ronghua Dai, Shaojie Wang
Topics & Concepts
ChemistryIndole testStereochemistryXanthine oxidaseAllopurinolPharmacophorePotencyMoietyIC50AmideFebuxostatEnzymeHyperuricemiaIn vitroBiochemistryUric acidMedicinePathologyGout, Hyperuricemia, Uric AcidEosinophilic Disorders and SyndromesUrticaria and Related Conditions