Application of film-forming solution as a transdermal delivery system of piperine-rich herbal mixture extract for anti-inflammation
Rathapon Asasutjarit, Papawee Sookdee, Sukitaya Veeranondha, Asira Fuongfuchat, Arunporn Itharat
Abstract
production by the RAW 264.7 cells and promotion of the cell phenotype polarization from M1 to M2. PHM-E FFS had low viscosity and exhibited the Newtonian behavior. It provided elastic PHM-E film with low tensile strength. The release profile of piperine from PHM-E film followed a zero-kinetic model. PHM-E FFS demonstrated compatibility with the skin cells, minimal ocular irritant when accidentally splashing into the eye and moderate-to-high potency for inhibition of inflammatory symptoms in the rats. PHM-E FFS thus had potential for use in the further clinical study to investigate its efficacy and safety in patients.
Topics & Concepts
PiperinePiperMedicineTraditional medicineProstaglandin E2Anti-inflammatoryTransdermalPharmacologyChemistryInternal medicinePiperaceae Chemical and Biological StudiesEssential Oils and Antimicrobial ActivityGinger and Zingiberaceae research