Cutaneous innate immune tolerance is mediated by epigenetic control of MAP2K3 by HDAC8/9
Yu Sawada, Teruaki Nakatsuji, Tatsuya Dokoshi, Nikhil N Kulkarni, Marc C. Liggins, George L. Sen, Richard L. Gallo
Abstract
These findings define a mechanism for the epidermis to regulate inflammation in the presence of ubiquitous TLR ligands.
Topics & Concepts
HDAC8Innate immune systemEpigeneticsInflammationImmunologyBiologyStimulationImmune toleranceKeratinocyteImmune systemCell biologyGeneticsNeuroscienceGeneCell cultureHistone methyltransferaseDermatology and Skin DiseasesNF-κB Signaling PathwaysPsoriasis: Treatment and Pathogenesis