Synthesis of 2H-Imidazo[2′,1':2,3] [1,3]thiazolo[4,5-e]isoindol-8-yl-phenylureas with promising therapeutic features for the treatment of acute myeloid leukemia (AML) with FLT3/ITD mutations
Vincenzo Cilibrasi, Virginia Spanò, Roberta Bortolozzi, Marilia Barreca, Maria Valeria Raimondi, Roberta Rocca, Annalisa Maruca, Alessandra Montalbano, Stefano Alcaro, Roberto Ronca, Giampietro Viola, Paola Barraja
Topics & Concepts
ChemistryMyeloid leukemiaCell cultureTyrosine kinaseFms-Like Tyrosine Kinase 3Cancer researchCell cycleMoietyStructure–activity relationshipKinaseLeukemiaStereochemistryApoptosisPharmacologyBiochemistrySignal transductionMutationGeneImmunologyIn vitroBiologyGeneticsQuinazolinone synthesis and applicationsClick Chemistry and ApplicationsCancer therapeutics and mechanisms