Toxicity and chemical transformation of silver nanoparticles in A549 lung cells: dose-rate-dependent genotoxic impact
Laure Bobyk, Adeline Tarantini, David Béal, Giulia Veronesi, Isabelle Kieffer, S. Motellier, Eugenia Valsami‐Jones, Iseult Lynch, Pierre‐Henri Jouneau, Karin Pernet‐Gallay, Catherine Aude‐Garcia, Sylvie Sauvaigo, Thierry Douki, Thierry Rabilloud, Marie Carrière
Abstract
Acute exposure of A549 cells to Ag-NPs induces stronger effects on DNA integrity, ROS level, cell metabolism and cell cycle than repeated exposure. Ag-NPs dissolves in both exposure conditions and Ag ions recombine with thiolated proteins.
Topics & Concepts
A549 cellToxicitySilver nanoparticleHuman lungDNA damageTransformation (genetics)ChemistryCellBiophysicsCell cycleDNACell biologyNanoparticleCell cultureMaterials scienceNanotechnologyBiochemistryBiologyGeneticsGeneOrganic chemistryNanoparticles: synthesis and applicationsAir Quality and Health ImpactsHeavy Metal Exposure and Toxicity