Click chemistry based synthesis, cytotoxic activity and molecular docking of novel triazole-thienopyrimidine hybrid glycosides targeting EGFR
Reham R. Khattab, Asma K. Alshamari, Allam A. Hassan, Hussein H. Elganzory, Wael A. El‐Sayed, Hanem M. Awad, Eman S. Nossier, Nasser A. Hassan
Abstract
exhibited excellent EGFR inhibitory activity in comparison with gefitinib. Furthermore, molecular modelling studies were performed to investigate the binding affinity of the most active compounds to EGFR enzyme.
Topics & Concepts
Click chemistryChemistryTriazoleDocking (animal)1,2,3-TriazoleStereochemistryCombinatorial chemistryMTT assayGlycosideCytotoxic T cellEGFR inhibitorsBiochemistryEpidermal growth factor receptorCell growthIn vitroOrganic chemistryReceptorNursingMedicineClick Chemistry and ApplicationsMonoclonal and Polyclonal Antibodies ResearchSynthesis and biological activity