Asymmetric synthesis of benzothiazolopyrimidines with high catalytic efficiency and stereoselectivity under bifunctional phosphonium salt systems
Dongming Lu, Jia‐Hong Wu, Jianke Pan, Chen Xue, Xiaoyu Ren, Tianli Wang
Abstract
An efficient formal [4+2] annulation between 2-benzothiazolimines and allenoates mediated by an amino acid-derived bifunctional phosphonium salt catalyst is developed. This protocol provides a new and facile synthetic approach to create a broad range of isothiourea-based benzothiazolopyrimidine derivatives under mild reaction conditions with high isolated yields and excellent diastereo- and enantioselectivities.
Topics & Concepts
BifunctionalPhosphonium saltPhosphoniumSalt (chemistry)AnnulationCatalysisStereoselectivityChemistryCombinatorial chemistryOrganic chemistrySynthesis and Catalytic ReactionsMulticomponent Synthesis of HeterocyclesChemical Synthesis and Analysis