Autophagy-lysosome inhibitor chloroquine prevents CTLA-4 degradation of T cells and attenuates acute rejection in murine skin and heart transplantation
Jikai Cui, Jizhang Yu, Heng Xu, Yanqiang Zou, Hao Zhang, Shanshan Chen, Sheng Le, Jing Zhao, Lang Jiang, Jiahong Xia, Jie Wu
Abstract
: Targeting CTLA-4 degradation provides a novel means to prevent transplant rejection and induce transplant tolerance.
Topics & Concepts
Cytotoxic T cellCD8CTLA-4TransplantationImmunologyT cellHeart transplantationMedicineFlow cytometryImmune systemIL-2 receptorCancer researchBiologyInternal medicineIn vitroBiochemistryImmune Cell Function and InteractionT-cell and B-cell ImmunologyImmunotherapy and Immune Responses