A dendritic/tumor fusion cell vaccine enhances efficacy of nanobody-based CAR-T cells against solid tumor
Shuyang Sun, Ziqiang Ding, Li Gao, Bruce D. Hammock, Xianing Huang, Zhi Ping Xu, Xuan Wang, Qihong Cheng, Fengzhen Mo, Wei Shi, Shenxia Xie, Aiqun Liu, Haixia Li, Xiaomei Yang, Xiaoling Lü
Abstract
We have innovatively shown that DC/tumor fusion vaccines significantly enhance the efficacy of Nb-CAR-T cells against solid tumors. This new strategy has provided a promising therapeutic platform for promoting the clinical treatment of CAR-T cells therapy.
Topics & Concepts
Chimeric antigen receptorCancer researchT cellAntigenImmunotherapyImmune systemIn vitroImmunologyMedicineChemistryBiochemistryCAR-T cell therapy researchMonoclonal and Polyclonal Antibodies ResearchImmunotherapy and Immune Responses