Oxygen-dependent changes in binding partners and post-translational modifications regulate the abundance and activity of HIF-1α/2α
Leonard A. Daly, Philip Brownridge, Michael Batie, Sónia Rocha, Violaine Sée, Claire E. Eyers
Abstract
in HIF-2α. These data will help to delineate the different physiological roles of these closely related isoforms in fine-tuning the hypoxic response.
Topics & Concepts
Hypoxia (environmental)OxygenCell biologyReactive oxygen speciesChemistryHypoxia-inducible factorsPost-translational regulationPosttranslational modificationBiologyBiochemistryEnzymePhosphorylationGeneOrganic chemistryCancer, Hypoxia, and MetabolismHigh Altitude and HypoxiaEicosanoids and Hypertension Pharmacology