A high-sucrose diet exacerbates the left ventricular phenotype in a high fat-fed streptozotocin rat model of diabetic cardiomyopathy
Anida Velagic, Mandy Li, Minh Deo, Jasmin Chendi Li, Helen Kiriazis, D. Donner, Dovile Anderson, Miles J. De Blasio, Owen L. Woodman, Barbara K. Kemp‐Harper, Cheng Xue Qin, Rebecca H. Ritchie
Abstract
Left ventricular dysfunction and adverse remodeling were more pronounced in diabetic rats that received low-dose streptozotocin (STZ) and a high-sucrose high-fat diet (HFD) compared with those on a moderate-sucrose HFD in combination with STZ. Our findings highlight the importance of sucrose content in diet composition, particularly in preclinical studies of diabetic cardiomyopathy, and demonstrate that low-dose STZ combined with a high-sucrose HFD is an appropriate rodent model of cardiomyopathy in type 2 diabetes.
Topics & Concepts
StreptozotocinDiabetic cardiomyopathyInternal medicineMedicineCardiologyCardiomyopathyDiabetes mellitusPhenotypeEndocrinologyBiologyHeart failureGeneBiochemistryCardiovascular Function and Risk FactorsDiet, Metabolism, and DiseasePancreatic function and diabetes