Oscillating lncRNA <i>Platr4</i> regulates <i>NLRP3</i> inflammasome to ameliorate nonalcoholic steatohepatitis in mice
Yanke Lin, Shuai Wang, Lu Gao, Ziyue Zhou, Ze‐Min Yang, Jingpan Lin, Shujing Ren, Huijie Xing, Baojian Wu
Abstract
inflammasome via intercepting NF-κB signaling. This lncRNA might be an attractive target that can be modulated to ameliorate the pathological conditions of steatohepatitis.
Topics & Concepts
InflammasomeSteatohepatitisTransactivationRNAGene knockdownImmunoprecipitationTranscription factorChemistryMessenger RNACell biologyTranscription (linguistics)RepressorBiologyMolecular biologyGeneBiochemistryFatty liverMedicineInternal medicineReceptorDiseasePhilosophyLinguisticsCancer-related molecular mechanisms researchLiver Disease Diagnosis and TreatmentInflammasome and immune disorders