Dysfunction of circulating CD3<sup>+</sup>CD56<sup>+</sup> NKT-like cells in type 2 diabetes mellitus
Ling Tang, Hui Wang, Kangli Cao, Cairui Xu, Along Ma, Meijuan Zheng, Yuanhong Xu, Min Zhang
Abstract
NKT-like cells. Importantly, we further found that the expression of Tim-3 in NKT-like cells from T2DM patients correlated positively with glycated hemoglobin (HbA1c) and fasting blood glucose (FBG) levels, as well as with diabetes duration. In conclusion, these results indicate that NKT-like cells from T2DM patients display an exhausted phenotype and reduced functionality. Moreover, Tim-3 expression on NKT-like cells likely serves a novel biomarker for duration of T2DM.
Topics & Concepts
Natural killer T cellType 2 Diabetes MellitusImmunologyNKG2DGlycated hemoglobinMedicineReceptorEndocrinologyDiabetes mellitusInternal medicineBiologyType 2 diabetesImmune systemCD8Cytotoxic T cellIn vitroBiochemistryImmune Cell Function and InteractionDiverse Education Studies and Reforms