Resveratrol inhibits the proliferation, invasion, and migration, and induces the apoptosis of human gastric cancer cells through the MALAT1/miR-383-5p/DDIT4 signaling pathway
Zhuying Yang, Liang Xia
Abstract
Background: We aimed to study the effects and potential mechanism of resveratrol (RS) in gastric cancer (GC). Methods: and negative interference control (si-NC). The Cell Counting Kit-8 method, scratch assay, and transwell assay were performed to evaluate cell proliferation, migration, and invasion. Additionally, flow cytometry was used to examine apoptosis, and the target relationship was examined by a luciferase-reporter gene analysis. Results: were reversed (all P<0.05). Conclusions: pathway and induced apoptosis.
Topics & Concepts
ApoptosisCell growthMolecular biologyTransfectionFlow cytometryGene silencingMALAT1Cancer researchResveratrolCellCell cultureMedicineBiologyDownregulation and upregulationGeneBiochemistryPharmacologyLong non-coding RNAGeneticsSirtuins and Resveratrol in MedicineMicroRNA in disease regulationCancer-related molecular mechanisms research