Point-of-care diagnostic tests for tuberculosis disease
Jiǎ Hóng, Hyeyoung Lee, Nishanth Venugopal Menon, Chwee Teck Lim, Luke P. Lee, Ong C
Abstract
Rapid diagnosis is one key pillar to end tuberculosis (TB). Point-of-care tests (POCTs) facilitate early detection, immediate treatment, and reduced transmission of TB disease. This Review evaluates current diagnostic assays endorsed by the World Health Organization and identifies the gaps between existing conventional tests and the ideal POCT. We discuss the commercial development of new rapid tests and research studies on nonsputum-based diagnostic biomarkers from both pathogen and host. Last, we highlight advances in integrated microfluidics technology that may aid the development of new POCTs.
Topics & Concepts
Point-of-care testingMedicineTuberculosisIntensive care medicineDiagnostic testDiseasePoint of carePillarPathologyPediatricsEngineeringStructural engineeringTuberculosis Research and EpidemiologyBiosensors and Analytical DetectionInnovative Microfluidic and Catalytic Techniques Innovation