Polymyxin Resistance and Heteroresistance Are Common in Clinical Isolates of <i>Achromobacter</i> Species and Correlate with Modifications of the Lipid A Moiety of Lipopolysaccharide
Lewis MacDonald, Sean Keenan, Flaviana Di Lorenzo, Nana Eghele Adade, D. Kenna, B. Cherie Millar, John E. Moore, José Ramos-Vivas, Antonio Molinaro, Miguel A. Valvano
Abstract
Achromobacter species can cause chronic and potentially severe infections in immunocompromised patients, especially in those with cystic fibrosis. Bacteria cannot be eradicated due to Achromobacter 's intrinsic multidrug resistance.
Topics & Concepts
PolymyxinLipid AAchromobacterMicrobiologyMoietyBiologyLipopolysaccharidePolymyxin BBacteriaChemistryAntibioticsPseudomonasGeneticsStereochemistryImmunologyInfections and bacterial resistanceAntibiotic Resistance in BacteriaBacterial biofilms and quorum sensing