mtDNA-cGAS-STING axis-dependent NLRP3 inflammasome activation contributes to postoperative cognitive dysfunction induced by sevoflurane in mice
Nan‐Shi‐Yu Yang, Wenjing Zhong, Han-Xi Sha, Chen‐Yu Zhang, Ling Jin, Jia‐Xi Duan, Jian‐Bing Xiong, Zhi-Jian You, Yong Zhou, Cha‐Xiang Guan
Abstract
the mPTP-VDAC channel inhibitor attenuated sevoflurane-induced mtDNA cytosolic escape and reduced cGAS-STING pathway activation in microglia, finally inhibiting the NLRP3 inflammasome activation. Therefore, regulating neuroinflammation by targeting the cGAS-STING pathway may provide a novel therapeutic target for POCD.
Topics & Concepts
InflammasomeNeuroinflammationSevofluraneMicrogliaPharmacologyChemistryAIM2Cell biologyMedicineImmunologyBiologyInflammationInflammasome and immune disordersinterferon and immune responsesImmune Response and Inflammation