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Neuropilin-1 is a T cell memory checkpoint limiting long-term antitumor immunity

Chang Liu, Ashwin Somasundaram, Sasikanth Manne, Angela M. Gocher, Andrea L. Szymczak-Workman, Kate M. Vignali, Ellen Scott, Daniel P. Normolle, E. John Wherry, Evan J. Lipson, Robert L. Ferris, Tullia C. Bruno, Creg J. Workman, Dario A.A. Vignali

2020Nature Immunology151 citationsDOIOpen Access PDF

Topics & Concepts

ImmunotherapyBlockadeImmune checkpointCancer researchCD8T cellNeuropilin 1ImmunologyBiologyCytotoxic T cellCancer immunotherapyMemory T cellCD44ImmunityImmune systemCellReceptorIn vitroVEGF receptorsGeneticsVascular endothelial growth factorBiochemistryCancer Immunotherapy and BiomarkersImmune Cell Function and InteractionCAR-T cell therapy research
Neuropilin-1 is a T cell memory checkpoint limiting long-term antitumor immunity | Litcius