NOX4: a potential therapeutic target for pancreatic cancer and its mechanism
Ya‐Wei Bi, Xiao Lei, Ningli Chai, Enqiang Linghu
Abstract
Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (NOX4) is one of the seven isoforms of NOX family, which is upregulated in pancreatic cancer cell, mouse model of pancreatic cancer and human pancreatic cancer tissue. NOX4 is a constitutively active enzyme that primarily produces hydrogen peroxide, which exhibits completely different properties from other subtypes of NOX family. More importantly, recent studies illuminate that NOX4 promotes pancreatic cancer occurrence and development in different ways. This review summarizes the potential roles and its mechanism of NOX4 in pancreatic cancer and explores NOX4 as the potential therapeutic target in pancreatic cancer.
Topics & Concepts
Pancreatic cancerNOX4Nicotinamide adenine dinucleotide phosphateNADPH oxidaseCancer researchCancerMechanism (biology)Hydrogen peroxideChemistryEnzymeMedicineBiologyOxidase testInternal medicineBiochemistryPhilosophyEpistemologyNeutrophil, Myeloperoxidase and Oxidative MechanismsImmune cells in cancerATP Synthase and ATPases Research