Development of a Continuous Photochemical Bromination/Alkylation Sequence En Route to AMG 423
Kyle W. Quasdorf, James I. Murray, Hanh Nho Nguyen, Maria Victoria Silva Elipe, Ari Ericson, Eric Kircher, Lianxiu Guan, Seb Caille
Abstract
The development of a photochemical bromination/alkylation sequence as part of a continuous process for the synthesis of an intermediate en route to AMG 423 is discussed. Highlights of this continuous process include a significant reduction in reaction time and the elimination of aqueous waste streams. Also discussed are mechanistic and kinetic studies offering insights into notable features of the photochemical bromination.
Topics & Concepts
HalogenationAlkylationChemistrySequence (biology)Process (computing)Aqueous solutionCombinatorial chemistryPhotochemistryOrganic chemistryCatalysisComputer scienceOperating systemBiochemistryOxidative Organic Chemistry ReactionsChemical Synthesis and ReactionsVanadium and Halogenation Chemistry