Plasmalogens improve swimming performance by modulating the expression of genes involved in amino acid and lipid metabolism, oxidative stress, and ferroptosis in an Alzheimer's disease zebrafish model
Junli Feng, Gongshuai Song, Yuanyuan Wu, Xi Chen, Jie Pang, Yaxi Xu, Qing Shen, Shunyuan Guo, Manman Zhang
Abstract
-exposed zebrafish partly by suppressing neuronal ferroptosis and accelerating synaptic transmission at the transcriptional level. This study provides evidence for PLs to be developed as a functional food supplement to relieve AD symptoms.
Topics & Concepts
ZebrafishOxidative stressNeuroprotectionLipid metabolismDownregulation and upregulationBiologyMetabolismGeneCell biologyBiochemistryNeuroscienceZebrafish Biomedical Research ApplicationsMicroRNA in disease regulationPregnancy and preeclampsia studies