N-Glycosylation of Rotavirus NSP4 Protein Affects Viral Replication and Pathogenesis
Jeffery A. Nurdin, Tomohiro Kotaki, Takahiro Kawagishi, Shintaro Sato, Moeko Yamasaki, Ryotaro Nouda, Shohei Minami, Yuta Kanai, Takeshi Kobayashi
Abstract
Rotavirus is the main cause of gastroenteritis in young children and infants worldwide, contributing to 128,500 deaths each year. Here, we used a reverse genetics approach to examine the role of NSP4 N-glycosylation.
Topics & Concepts
GlycosylationBiologyViral replicationVirologyVirusN-linked glycosylationViral pathogenesisRotavirusRecombinant DNAGlycoproteinMolecular biologyGlycanGeneGeneticsViral gastroenteritis research and epidemiologyAnimal Virus Infections StudiesViral Infections and Immunology Research