Betaine host–guest complexation with a calixarene receptor: enhanced <i>in vitro</i> anticancer effect
Sherif Ashraf Fahmy, Fortuna Ponte, Iten M. Fawzy, Emilia Sicilia, Hassan Mohamed El-Said Azzazy
Abstract
The complexation between <italic>p</italic>-SC4 and betaine was thoroughly investigated experimentally and computationally. A remarkable enhancement of the cytotoxic activities of betaine/<italic>p</italic>-SC4 complex was observed as compared to free betaine.
Topics & Concepts
BetaineHeLaChemistryIn vitroStoichiometryStereochemistryMedicinal chemistryOrganic chemistryBiochemistrySupramolecular Chemistry and ComplexesLanthanide and Transition Metal ComplexesMolecular Sensors and Ion Detection