Dual-locus, dual-HDR editing permits efficient generation of antigen-specific regulatory T cells with robust suppressive activity
Martina S. Hunt, Soo Jung Yang, Emma Mortensen, Ahmad Boukhris, Jane H. Buckner, Peter J. Cook, David J. Rawlings
Topics & Concepts
Dual (grammatical number)Locus (genetics)AntigenComputational biologyBiologyDual roleCell biologyGeneChemistryGeneticsCombinatorial chemistryLiteratureArtCAR-T cell therapy researchCRISPR and Genetic EngineeringImmune Cell Function and Interaction