A neuropathy‐associated kinesin KIF1A mutation hyper‐stabilizes the motor‐neck interaction during the ATPase cycle
Manatsu Morikawa, Nivedita U. Jerath, T. Ogawa, Momo Morikawa, Yosuke Tanaka, Michael E. Shy, Stephan Züchner, Nobutaka Hirokawa
Topics & Concepts
KinesinBiologyATP hydrolysisHereditary spastic paraplegiaMutantATPaseMutationCell biologyMolecular motorMicrotubuleMotor proteinBiophysicsGeneticsBiochemistryPhenotypeEnzymeGeneMicrotubule and mitosis dynamicsCellular transport and secretionHereditary Neurological Disorders