Characterization of drug-induced human mitochondrial ADP/ATP carrier inhibition
Stephany Jaiquel Baron, Martin King, Edmund R.S. Kunji, Tom J.J. Schirris
Abstract
Consequently, we have provided a straightforward model system to investigate AAC inhibition and have gained new insights into the chemical compound features important for inhibition. Better evaluation methods of drug-induced inhibition of mitochondrial transport proteins will contribute to the development of drugs with an enhanced safety profile.
Topics & Concepts
MitochondrionMitochondrial toxicityDrugSuraminCytosolATP–ADP translocaseBiochemistryChemistryAdenosine triphosphateBinding siteDrug developmentDrug discoveryPharmacologyIn vitroBiophysicsBiologyEnzymeInner mitochondrial membraneMitochondrial Function and PathologyMetabolism and Genetic DisordersATP Synthase and ATPases Research