Catalyst-Controlled C–H Transformation of Pyrazolidinones with 1,3-Diynes for Highly Selective Synthesis of Functionalized Bisindoles and Indoles
Yi Luo, Lin Dong
Abstract
An efficacious synthetic solution to offer functionalized bisindoles and indoles has been developed based on catalyst-controlled C-H functionalization of pyrazolidinones and 1,3-diynes with highly selective control of both chemoselectivity and regioselectivity. This straightforward pathway conquers chemo- and regioselectivity challenges concerning the use of 1,3-diynes.
Topics & Concepts
ChemoselectivityRegioselectivityChemistryCatalysisSurface modificationCombinatorial chemistryTransformation (genetics)Organic chemistryPhysical chemistryBiochemistryGeneCatalytic C–H Functionalization MethodsCatalytic Alkyne ReactionsSynthesis of Indole Derivatives