miR-125a-5p-abundant exosomes derived from mesenchymal stem cells suppress chondrocyte degeneration via targeting E2F2 in traumatic osteoarthritis
Qingqing Xia, Quan Wang, Feng Lin, Junjuan Wang
Abstract
. Besides that, the mice model with post-traumatic OA turned out that exosomal miR-125a-5p might beget an alleviation in chondrocyte extracellular matrix degradation. All these outcomes revealed that BMSCs-derived exosomal miR-125a-5p is a positive regulator for chondrocyte migration and inhibit cartilage degeneration We thus were reasonable to believe that transferring of exosomal miR-125a-5p is a prospective strategy for OA treatment.
Topics & Concepts
Mesenchymal stem cellOsteoarthritisChondrocyteMicrovesiclesDegeneration (medical)MedicineCell biologyCancer researchCartilageBiologyPathologymicroRNAAnatomyGeneBiochemistryAlternative medicineExtracellular vesicles in diseaseMicroRNA in disease regulationOsteoarthritis Treatment and Mechanisms