Skeletal muscle properties show collagen organization and immune cell content are associated with resistance exercise response heterogeneity in older persons
Douglas E. Long, Bailey D. Peck, Kaleen M. Lavin, Cory M. Dungan, Kate Kosmac, S. Craig Tuggle, Marcas M. Bamman, Philip A. Kern, Charlotte A. Peterson
Abstract
Extensive analyses of muscle features associated with muscle size and resistance training response in older persons, including sex differences, and evaluation of multiple measures of hypertrophy are discussed. Collagen organization and CD11b-expressing immune cells offer potential new targets to augment growth response in older individuals. A hypertrophy composite score reveals that changes in immune cells, myonuclei, and capillary density are critically important for overall muscle growth while sc-RNAseq reveals evidence for macrophage heterogeneity.
Topics & Concepts
Muscle hypertrophySkeletal muscleImmune systemResistance trainingBiologyInternal medicinePhysiologyEndocrinologyImmunologyPsychologyMedicineExercise and Physiological ResponsesMuscle Physiology and DisordersNutrition and Health in Aging