DNA-methylation-induced silencing of DIO3OS drives non-small cell lung cancer progression via activating hnRNPK-MYC-CDC25A axis
Meichun Zhang, Jing Wu, Weinong Zhong, Ziwen Zhao, Weiguo He
Abstract
transcription and translation, and therefore remarkably decreased the expression of MYC and CDC25A, a downstream target of MYC. Additionally, depletion of hnRNPK blocked the tumor-suppressive roles of DIO3OS in NSCLC. In conclusion, these findings identified DIO3OS as an important protective factor against NSCLC via modulating hnRNPK-MYC-CDC25A axis.
Topics & Concepts
Cancer researchDNA methylationCarcinogenesisBiologyGene silencingMethylationEpigeneticsEctopic expressionTranscription factorCDC25ACell cycleCellCancerDNAGene expressionCell cycle checkpointCell cultureGeneGeneticsCancer-related molecular mechanisms researchRNA modifications and cancerCircular RNAs in diseases