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Oxidative stress and caspase 3/Gsdme-dependent pyroptosis contributes to high fat diet induced-intestinal inflammation and lipotoxicity via Srebp1 cleavage at D444 site by caspase 3

An-Gen Yu, Xiaolei Wei, Ester Zito, Hua Zheng, Chong-Chao Zhong, Yulong Gong, Zhi Luo

2025The Journal of Nutritional Biochemistry5 citationsDOI

Topics & Concepts

PyroptosisLipotoxicitySterol regulatory element-binding proteinOxidative stressInflammationInflammasomeCaspase 1ApoptosisChemistryCaspase 3Cleavage (geology)Internal medicineCell biologyEndocrinologyBiologyMedicineProgrammed cell deathBiochemistryCholesterolSterolDiabetes mellitusPaleontologyInsulin resistanceFracture (geology)Inflammasome and immune disordersDiet, Metabolism, and DiseaseLiver Disease Diagnosis and Treatment
Oxidative stress and caspase 3/Gsdme-dependent pyroptosis contributes to high fat diet induced-intestinal inflammation and lipotoxicity via Srebp1 cleavage at D444 site by caspase 3 | Litcius