Synthesis of tryptanthrin appended dispiropyrrolidine oxindoles and their antibacterial evaluation
Sruthi Sudheendran Leena, Abdul Akhir, Deepanshi Saxena, Rahul Maitra, Sidharth Chopra, Ani Deepthi
Abstract
The synthesis of sixteen tryptanthrin appended dispiropyrrolidine oxindoles, employing [3 + 2] cycloaddition of tryptanthrin-derived azomethine ylides with isatilidenes, and their detailed antibacterial evaluation is described.
Topics & Concepts
OxindoleChemistryIn vitroAntibacterial activityCombinatorial chemistryCycloadditionSelectivityIsatinMicrobiologyBacteriaOrganic chemistryBiologyBiochemistryCatalysisGeneticsQuinazolinone synthesis and applicationsSynthesis and Biological EvaluationPhenothiazines and Benzothiazines Synthesis and Activities