Decarboxylative Hydroxylation of Benzoic Acids
Wanqi Su, Peng Xu, Tobias Ritter
Abstract
Herein, we report the first decarboxylative hydroxylation to synthesize phenols from benzoic acids at 35 °C via photoinduced ligand-to-metal charge transfer (LMCT)-enabled radical decarboxylative carbometalation. The aromatic decarboxylative hydroxylation is synthetically promising due to its mild conditions, broad substrate scope, and late-stage applications.
Topics & Concepts
HydroxylationChemistryPhenolsSubstrate (aquarium)Benzoic acidOrganic chemistryDecarboxylationLigand (biochemistry)Combinatorial chemistryCatalysisBiochemistryReceptorEnzymeGeologyOceanographyRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques