Copper-Mediated <i>ortho</i>-C–H Amination Using DMF as the Amine Source
Tai-Jin Cheng, Junjie Chen, Peng Wu, Hui Xu, Hui‐Xiong Dai
Abstract
-C-H amination of anilines using oxalamide as the directing group and DMF as the amination reagent. This protocol tolerates various functional groups and shows good heterocyclic compatibility. Late-stage dimethylamination of drugs demonstrated the synthetic practicality of the protocol. Mechanistic experiments indicate that a radical pathway may be involved in the reaction.
Topics & Concepts
AminationChemistryReagentAmine gas treatingFunctional groupCombinatorial chemistryCopperOrganic chemistryMoleculeCatalysisPolymerCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsSulfur-Based Synthesis Techniques