Unprecedented chemoselective Ru(<scp>iii</scp>)-catalyzed [3 + 2] annulation of enaminones with iodonium ylides for the synthesis of functionalized 3a,7a-dihydroxy hexahydro-4<i>H</i>-indol-4-ones
Mingshuai Zhang, Longkun Chen, Zhuoyuan Liu, Jiuzhong Huang, Fuchao Yu
Abstract
Highly functionalized 3a,7a-dihydroxy hexahydro-4 H -indol-4-ones were efficiently synthesized via a Ru( iii )-catalyzed alkenyl C(sp 2 )–H bond functionalization/[3 + 2] annulation reaction between readily available enaminones and iodonium ylides.
Topics & Concepts
AnnulationChemistryCatalysisSurface modificationCombinatorial chemistryMedicinal chemistryStereochemistryOrganic chemistryPhysical chemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsOxidative Organic Chemistry Reactions