Targeting the adenosinergic axis in cancer immunotherapy: Insights into A2A and A2B receptors and novel clinical combination strategies
Iván Rodríguez-Pampín, Lucía González-Pico, Asier Selas, Antonio Andújar, Rubén Prieto‐Díaz, Eddy Sotelo
Topics & Concepts
AdenosinergicAdenosineAdenosine receptorCancer researchTumor microenvironmentPurinergic signallingImmune systemBiologyStromal cellReceptorCancerPharmacologyMedicineSignal transductionImmunologyAngiogenesisImmunotherapyCancer immunotherapyAdenosine A2A receptorAdenosine A3 receptorImmune checkpointCancer cellT cellIpilimumabG protein-coupled receptorFunctional selectivityAdenosine A2B receptorAdoptive cell transferImmunosuppressionAdenosine and Purinergic SignalingCancer Immunotherapy and BiomarkersPeptidase Inhibition and Analysis