Development of novel isatin thiazolyl-pyrazoline hybrids as promising antimicrobials in MDR pathogens
Tarfah Al‐Warhi, Diaaeldin M. Elimam, Zainab M. Elsayed, Marwa M. Abdel‐Aziz, Raed M. Maklad, Ahmed A. Al‐Karmalawy, Kamyar Afarinkia, Mohammed A. S. Abourehab, Hatem A. Abdel‐Aziz, Wagdy M. Eldehna
Abstract
As promising antimicrobials against MDR pathogens, two novel series of isatin thiazolyl-pyrazoline conjugates were developed. Compounds 9f and 10h were the most effective against the tested MDR strains.
Topics & Concepts
AntimicrobialMicrobiologyBroth microdilutionMultiple drug resistanceFluconazoleIsatinBacteriaStaphylococcus aureusChemistryCorpus albicansVancomycinCandida albicansMethicillin-resistant Staphylococcus aureusBiologyAntibioticsMinimum inhibitory concentrationAntifungalOrganic chemistryGeneticsSynthesis and biological activityCancer therapeutics and mechanismsAntimicrobial Peptides and Activities