Matrix stiffness triggers chemoresistance through elevated autophagy in pancreatic ductal adenocarcinoma
Haopeng Pan, Shajun Zhu, Tiancheng Gong, Di Wu, Yahong Zhao, Jiashuai Yan, Chaolun Dai, Yan Huang, Yumin Yang, Yibing Guo
Abstract
autophagy. Furthermore, RNA-seq results showed that miR-1972 may regulate autophagy level in response to matrix stiffness. Overall, our research shed light on the synergistic therapy of PDAC combined with gemcitabine and chloroquine, which is conducive to promoting a therapeutic effect.
Topics & Concepts
AutophagyPancreatic ductal adenocarcinomaCancer researchMatrix (chemical analysis)ChemistryAdenocarcinomaCell biologyMatrix metalloproteinasePancreatic cancerStiffnessBiologyInternal medicineMedicineApoptosisCancerBiochemistryEngineeringStructural engineeringChromatographyAutophagy in Disease and TherapyPhagocytosis and Immune Regulation