Protection from Lethal Clostridioides difficile Infection via Intraspecies Competition for Cogerminant
Jhansi L. Leslie, Matthew L. Jenior, Kimberly C. Vendrov, Alexandra K. Standke, Madeline R. Barron, Tricia J. O’Brien, Lavinia V. Unverdorben, Pariyamon Thaprawat, Ingrid L. Bergin, Patrick D. Schloss, Vincent B. Young
Abstract
, a current clinical therapy, provides protection from reinfection. Furthermore, our work suggests that targeting nutrients utilized by all life stages could be an improved strategy for bacterial therapeutics that aim to restore colonization resistance in the gut.
Topics & Concepts
ClostridioidesVirulenceMicrobiologyStrain (injury)AntibioticsColitisGlycineBiologyBacteriaCompetition (biology)VirologyImmunologyAmino acidEcologyGeneGeneticsAnatomyClostridium difficile and Clostridium perfringens researchMicroscopic ColitisHelicobacter pylori-related gastroenterology studies