Enantioselective Pd-catalyzed dearomative reductive Heck and domino Heck–Suzuki reactions of 2-CF<sub>3</sub>-indoles
Ren‐Xiao Liang, J.F. Chen, Yingying Huang, Yaping Yu, Han‐Yue Zhang, Yu-Feng Song, Gavin Chit Tsui, Yi‐Xia Jia
Abstract
Highly enantioselective palladium-catalyzed dearomative reductive Heck and domino Heck–Suzuki reactions of 2-CF 3 -indoles have been developed towards the synthesis of indolines bearing trifluoromethyl quaternary stereocenters.
Topics & Concepts
StereocenterEnantioselective synthesisHeck reactionChemistryDominoCatalysisSuzuki reactionPhosphoramiditeCombinatorial chemistryOrganic chemistryPalladiumMedicinal chemistryOligonucleotideDNABiochemistryCatalytic C–H Functionalization MethodsFluorine in Organic ChemistryCatalytic Cross-Coupling Reactions