Coagulopathy in Acute Puumala Hantavirus Infection
Sirpa Koskela, Satu Mäkelä, Tomas Strandin, Antti Vaheri, Tuula K. Outinen, Lotta Joutsi‐Korhonen, Ilkka Pörsti, Jukka Mustonen, Outi Laine
Abstract
Puumala hantavirus (PUUV) causes a hemorrhagic fever with renal syndrome (HFRS), also called nephropathia epidemica (NE), which is mainly endemic in Europe and Russia. The clinical features include a low platelet count, altered coagulation, endothelial activation, and acute kidney injury (AKI). Multiple connections between coagulation pathways and inflammatory mediators, as well as complement and kallikrein-kinin systems, have been reported. The bleeding symptoms are usually mild. PUUV-infected patients also have an increased risk for disseminated intravascular coagulation (DIC) and thrombosis.
Topics & Concepts
HantavirusCoagulopathyPuumala virusHantavirus InfectionVirologyMedicineImmunologyIntensive care medicineInternal medicineVirusViral Infections and VectorsOptimism, Hope, and Well-being