Lycopene prevents DEHP-induced testicular endoplasmic reticulum stress <i>via</i> regulating nuclear xenobiotic receptors and unfolded protein response in mice
Yi Zhao, Ling-Ge Cui, Milton Talukder, Jia-Gen Cui, Hao Zhang, Jin‐Long Li
Abstract
The present study suggested that LYC prevents DEHP-induced ER stress in testis via regulating NXRs and UPR ER . This study indicated that NXRs and UPR ER might be a new strategy for the prevention of DEHP-induced testicular toxicity by LYC.
Topics & Concepts
Endoplasmic reticulumNuclear receptorXenobioticUnfolded protein responseChemistryCell biologyReceptorFight-or-flight responsePharmacologyBiochemistryBiologyEnzymeTranscription factorGeneEndoplasmic Reticulum Stress and DiseaseCoenzyme Q10 studies and effectsAldose Reductase and Taurine